Specialized care for children with inflammatory diseases and genetic immune dysregulation..

About Us

About Us

Dr. Pallavi Pimpale is a highly skilled Pediatric Rheumatologist specializing in the diagnosis, treatment, and management of complex autoimmune and autoinflammatory diseases in children. With over a decade of experience, she combines expertise in genetics, molecular diagnostics, and advanced laboratory evaluations to provide cutting-edge care.

Dr. Pallavi has trained at renowned institutions, including Jaslok Hospital, Mumbai, and the National Institutes of Health (NIH), USA, where she conducted pioneering research on autoinflammatory diseases under the mentorship of Dr. Daniel Kastner. She collaborates with global experts to advance the understanding and treatment of pediatric rheumatic conditions.

About us

Pediatric Rheumatologist, Autoinflammatory Disease Specialist, NIH-Trained Research Clinician

Dr. Pallavi Pimpale is a highly trained and compassionate Pediatric Rheumatologist with a dedicated focus on autoimmune and autoinflammatory diseases in children. With over a decade of experience across leading medical institutions in India and the United States, she blends expert clinical care with a strong foundation in translational science and medical research.

Her career journey spans structured pediatric training, hands-on hospital experience, advanced fellowships, and international research that positions her as one of India’s few specialists with in-depth exposure to rare genetic inflammatory disorders in children.

Trained at Premier Pediatric Hospitals

Clinical Training & Experience

Dr. Pimpale began her medical career with an M.B.B.S., followed by a DNB in Pediatrics at Lotus Children’s Hospital, Hyderabad, where she built a strong base in pediatric healthcare. She further honed her pediatric experience as a Clinical Assistant at P.D. Hinduja Hospital and Research Center, Mumbai, where she worked with a diverse spectrum of child health conditions.

Her interest in complex immune-mediated diseases led her to pursue a prestigious Fellowship in Pediatric Rheumatology, accredited by the Indian Academy of Pediatrics, at Jaslok Hospital and Research Center, Mumbai. Under the mentorship of Dr. Raju Khubchandani, a respected authority in the field, she developed advanced skills in diagnosing and managing pediatric autoimmune and inflammatory diseases.

She later served as Junior Consultant in Pediatric Rheumatology at NH SRCC Children’s Hospital, where she worked with multidisciplinary teams to treat children with chronic and debilitating inflammatory conditions.

NIH fellowship in rare diseases

Global Research Leadership: Fellowship at NIH, USA

In 2020, Dr. Pimpale was selected for a highly competitive five-year research fellowship at the National Institutes of Health (NIH), Bethesda, Maryland, USA, under the mentorship of Dr. Daniel L. Kastner—an internationally renowned expert in autoinflammatory diseases.

 

At the NIH, she specialized in rare autoinflammatory disorders, working with some of the world’s most diagnostically complex pediatric cases. Her research contributed to the discovery and understanding of novel genetic syndromes that cause episodes of unexplained inflammation in children.

 

This unique global experience has empowered her to bring cutting-edge science into clinical practice, particularly in early diagnosis, precision treatment, and genetics-based evaluation of pediatric rheumatologic diseases.

Personalized, science-backed pediatric care

A Holistic, Evidence-Based Approach to Care

Dr. Pallavi Pimpale is committed to delivering evidence-driven, personalized care that supports not just the child but the entire family. She believes in a holistic approach that balances medical expertise with compassionate support—especially when families are navigating the uncertainty of chronic conditions.

Her clinical focus includes:

  • Juvenile Idiopathic Arthritis (JIA)

  • Systemic Lupus Erythematosus (SLE)

  • Autoinflammatory Syndromes (e.g., TRAPS, FMF, NOMID)

  • Vasculitis, Kawasaki Disease

  • Rare Pediatric Autoimmune Conditions

With a deep understanding of both diagnostic complexity and family dynamics, she provides clarity, guidance, and cutting-edge treatment options tailored to each child’s unique medical needs.

Publications

  • Triaille, C., Rao, N.M., Rice, G.I. et al. Hereditary C1q Deficiency is Associated with Type 1 Interferon-Pathway Activation and a High Risk of Central Nervous System Inflammation. J Clin Immunol 44, 185 (2024).
  • Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nat Immunol, 25, 764–777.
  • Interrupting an IFN-γ-dependent feedback loop in the syndrome of pyogenic arthritis with pyoderma gangrenosum and acne. Annals of the Rheumatic Diseases, 83(6), 787-798.
  • Standardized nailfold capillaroscopy in children with rheumatic diseases: a worldwide study. Rheumatology, 62(4), April 2023, Pages 1605.
  • Variant STAT4 and response to ruxolitinib in an autoinflammatory syndrome. N Engl J Med, 2023;388:2241-2252.
  • Case report: Novel variants in RELA associated with familial Behcet’s-like disease. Front. Immunol., 28 February 2023.
  • Wide variation in glucocorticoid dosing in paediatric ANCA-associated vasculitis with renal disease: a paediatric vasculitis initiative study. Clin Exp Rheumatol, 2022.
  • Is Anti-NXP2 Autoantibody a Risk Factor for Calcinosis and Poor Outcome in Juvenile Dermatomyositis Patients? Front Pediatr, 8, 23 February 2022.
  • Clinical features, severity and outcome of acute pancreatitis in systemic lupus erythematosus. Rheumatol Int., 42, 1363–1371 (2022).
  • Deficiency of Adenosine Deaminase 2 (DADA2): One Disease, Several Faces. Indian J Pediatr, 88, 828–830 (2021).
  • Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death. Cell, 184(17), 2021, Pages 4447-4463.e20.
  • Majeed Syndrome: Five Cases with Novel Mutations from Unrelated Families in India with a Review of Literature. The Journal of Rheumatology, May 2021.
  • Deficiency of Adenosine Deaminase 2 in Adults and Children: Experience from India. Arthritis Rheumatol, 2021; 73(2): 276–285.
  • Development and initial validation of a composite disease activity score for systemic juvenile idiopathic arthritis. Rheumatology, 59(11), November 2020, Pg 3505-3514.
  • Steroid-dependent Kimura Disease in a Child Treated with Cetirizine and Montelukast. Indian Pediatr, 2020 Aug 15;57(8):777-778.
  • Genotype and functional correlates of disease phenotype in deficiency of adenosine deaminase 2 (DADA2). J Allergy Clin Immunol, 145(6), 2020, Pages 1664-1672.e10.
  • Detection of a novel mutation in NLRP3/CIAS1 gene in an Indian child with Neonatal-Onset Multisystem Inflammatory Disease (NOMID). Clin Rheumatol, 2019 Feb;38(2):403-406.